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我国已步入老龄化阶段,老年群体的健康状况一直备受重视.阿尔兹海默病(Alzheimer's disease,AD)是最常见的老年痴呆类型,主要以β-淀粉样蛋白异常沉积形成老年斑(Senile Plaques,SP)和过度磷酸化Tau蛋白聚集形成的神经纤维缠结(Neurofibrillary tangles,NFTs)为主要病理特征,临床表现为渐进性认知功能障碍及行为能力的欠缺,严重影响老年人身体健康及生活质量,发病机制十分复杂,目前尚无特效药.因此,如何维持和改善老年人的认知功能,提高其晚年的生活质量,已成为当今多学科研究者关注的热点问题.从β-淀粉样蛋白异常沉积、脑内神经细胞内Tau蛋白过度磷酸化引起的神经原纤维缠结、神经炎症反应、线粒体功能障碍、突触转导功能异常等方面入手,对阿尔兹海默病的发病诱因加以简要综述.
Abstract：China has entered the aging stage, and the health status of the elderly has been attached great importance. Alzheimer's disease(AD) is the most common type of senile dementia. It is mainly characterized by abnormal deposition of β-amyloid protein and formation of senile plaques(SP) and neurofibrillary tangles(NFTs) formed by excessive phosphorylation of tau protein. Its clinical manifestations are progressive cognitive impairment and lack of behavior ability, which seriously affect the health and quality of life of the elderly. However, there is no specific drug, and the pathogenesis is very complex. Therefore, how to maintain and improve the cognitive function of the elderly and improve their quality of life in their later years has become a hot issue of multidisciplinary researchers. In this paper, the pathogenesis of Alzheimer's disease is summarized from the following aspects such as abnormal deposition of amyloid beta protein, neurofibrillary tangles caused by tau protein hyperphosphorylation in brain cells, neuroinflammatory response, mitochondrial dysfunction, and abnormal synaptic transduction function, etc.
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基本信息:
中图分类号:R749.16
引用信息:
[1]宋博雅.阿尔兹海默症发病机制的研究进展[J].西安文理学院学报(自然科学版),2020,23(04):77-79+92.
基金信息:
西安体育学院院管课题资助项目(2016QN001)
2020-10-15
2020-10-15